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The study examines how Org OD 14 affects beta-endorphin levels in both rats after ovariectomy and post-menopausal women.

April 27, 2026Open Access

Effects of Org OD 14 on pituitary and peripheral beta-endorphin in castrated rats and post-menopausal women.

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Randomized trial evaluates Org OD 14's effects on beta-endorphin in castrated rats and post-menopausal women, indicating hormonal treatment benefits.

The study examines how Org OD 14 affects beta-endorphin levels in both rats after ovariectomy and post-menopausal women.
Groups of ovariectomized rats (N=9) received Org OD 14 or placebo over 14 days.
Plasma and pituitary beta-endorphin levels were measured using double-antibody radioimmunoassay (RIA).
Post-menopausal women were treated with Org OD 14 or placebo for 6 months to compare plasma beta-endorphin levels.
Org OD 14 treatment significantly increased beta-endorphin levels in both plasma and pituitary lobes in rats (p<0.05).
In post-menopausal women, beta-endorphin and beta-lipotrophin levels were significantly higher in the Org OD 14 group from month two onwards (p<0.01).
Only transient effects on plasma lipids and lipoproteins were observed with Org OD 14 treatment.

Genazzani et al. (1987) studied this question.

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Randomized trial evaluates Org OD 14's effects on beta-endorphin in castrated rats and post-menopausal women, indicating hormonal treatment benefits.