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This research aims to elucidate the role of endothelial RhoA in both embryonic and postnatal vascular development through KLF2–Notch1 signaling.

Endothelial RhoA is essential for embryonic and postnatal vascular development by regulating KLF2–Notch1 signaling

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This research aims to elucidate the role of endothelial RhoA in both embryonic and postnatal vascular development through KLF2–Notch1 signaling.
Generated mice with endothelium-specific conditional knockout of RhoA, both constitutive and tamoxifen-inducible.
Analyzed vascular abnormalities during embryogenesis and postnatal retinal vascular plexus development.
Used luciferase analysis to determine the interaction between KLF2 and Notch1 expression.
Constitutive and inducible RhoA cKO mice died by embryonic day 11.5, showing severe vasculature abnormalities.
Inducible RhoA cKO mice exhibited reduced radial outgrowth and density of vascular plexus at postnatal day 10.
KLF2 was identified as a negative regulator of Notch1 expression, phosphorylated by the RhoA-ROCK pathway.

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Randomized trial uncovers the role of endothelial RhoA in vascular development, indicating its significance for healthy growth.

Tesega et al. (2026) studied this question.

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