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April 27, 2026Open Access

De novo decorin gene expression suppresses the malignant phenotype in human colon cancer cells.

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Authors

SMSantra MSTSkorski TLELattime Ec

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Overview

Randomized trial demonstrates tumor suppression in colon cancer cells via decorin gene expression, suggesting therapeutic potential.

Key Points

  • To investigate the role of decorin gene expression in suppressing the malignant behavior of human colon cancer cells.
  • Human colon cancer cells were stably transfected with decorin cDNA.
  • Growth rate and tumor formation were assessed in vitro and in scid/scid mice.
  • Effects of decorin antisense oligodeoxynucleotides on growth suppression were analyzed.
  • Cells showed reduced in vitro growth rates and formed small colonies in soft agar.
  • No tumors developed in scid/scid mice injected with decorin-expressing cells.
  • Transfected clones were arrested in the G1 phase of the cell cycle.

Cite This Study

M et al. (1995) studied this question.

synapsesocial.com/papers/69eefd43fede9185760d3f80https://doi.org/10.1073/pnas.92.15.7014
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