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This research aims to understand the role of IFNγ in controlling Mycobacterium tuberculosis infection in macaques.

April 27, 2026Nature CommunicationsOpen Access

IFNγ blockade in Mycobacterium tuberculosis infected macaques alters the granuloma environment but not bacterial control

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Randomized trial evaluates IFNγ blockade's effect on bacterial control and immune response in macaques, suggesting altered immunity.

This research aims to understand the role of IFNγ in controlling Mycobacterium tuberculosis infection in macaques.
Blocked IFNγR1 signaling in macaques at different times post-infection.
Monitored 18 FDG-PET/CT scores and inflammatory responses.
Analyzed the impact of IFNγ blockade on bacterial loads and granuloma structure.
IFNγ blockade reduced FDG-PET/CT scores but did not change bacterial loads (p-value not specified).
Changes in immune responses and granuloma structure were observed despite unchanged bacterial control.
Mice models overestimate the role of IFNγ in resistance to TB due to species-specific responses.

Sakai et al. (2026) studied this question.

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