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April 27, 2026Solid State Nuclear Magnetic ResonanceOpen Access

Higher Magnetic Field NMR Renders Resolution Enhancement on Ganglioside GD3 Catalyzed Heterogeneous Aβ42 Aggregates

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Authors

JSJhinuk SahaFlorida State UniversityTRThirupati RavulaResonance Research (United States)ARAyyalusamy RamamoorthyFlorida State University

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Implication

Randomized trial shows enhanced spectral resolution in ganglioside GD3-catalyzed Aβ42 aggregates, indicating improved characterization potential.

Key Points

  • This research evaluates the use of high-field solid-state NMR to characterize ganglioside GD3-catalyzed Aβ42 aggregates, focusing on overcoming hurdles posed by their heterogeneity.
  • Utilized 1.1 GHz solid-state NMR to study GD3-catalyzed Aβ42 aggregates.
  • Analyzed uniformly-labeled Aβ42 incubated with GD3 under magic-angle spinning conditions.
  • Conducted 13C CPMAS spectra and 2D 13C-13C chemical shift correlation experiments using CORD mixing.
  • 1.1 GHz spectra showed enhanced sensitivity and improved spectral resolution compared to 600 MHz.
  • Better resolved resonances corresponded to selectively structured regions of Aβ42.
  • Presence of an ordered core within the lipid-associated aggregates was indicated.

Cite This Study

Saha et al. (2026) studied this question.

synapsesocial.com/papers/69eefd82fede9185760d43a1https://doi.org/10.1016/j.ssnmr.2026.102093
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