Palladium-catalyzed domino sequence of ortho-X-allenyl tethered aryl isocyanides: access to fused benzazole frameworks

Leyla Saeifard; Kamran Amiri; Hormoz Khosravi; Felix Bauer; Frank - Rominger; Bernhard Breit; Thomas J.J. Müller; Saeed Balalaie

doi:10.1039/d6qo00197a

January 1, 2026Organic Chemistry Frontiers

Palladium-catalyzed domino sequence of ortho-X-allenyl tethered aryl isocyanides: access to fused benzazole frameworks

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Key Points

This research aims to explore a new palladium-catalyzed domino sequence using ortho-X-allenyl tethered aryl isocyanides to synthesize fused benzazole frameworks.
Developed a palladium-catalyzed domino sequence using ortho-X-allenyl tethered aryl isocyanides as substrates.
Synthesized a variety of fused benzazole frameworks through this novel reaction.
Characterized products using standard analytical techniques.
Successfully synthesized multiple fused benzazole structures with high efficiency.
Reaction conditions optimized to enhance product yield and selectivity.
Significant reduction in synthesis time compared to traditional methods.

Implication

Demonstrates novel palladium-catalyzed reactions in aryl isocyanides, suggesting broader synthetic applications.

Abstract

A palladium-catalyzed domino sequence has been unlocked through the advent of a hitherto unreported class of ortho -X-allenyl tethered aryl isocyanides, highly reactive scaffolds that enable streamlined access to fused polycyclic...

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Cite This Study

Saeifard et al. (2026) studied this question.

synapsesocial.com/papers/69eefd82fede9185760d43da https://doi.org/10.1039/d6qo00197a

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Palladium-catalyzed domino sequence of ortho-X-allenyl tethered aryl isocyanides: access to fused benzazole frameworks

Key Points

Implication

Abstract

Discussion

Cite This Study

Palladium-catalyzed domino sequence of ortho-X-allenyl tethered aryl isocyanides: access to fused benzazole frameworks

Key Points

Implication

Abstract

Discussion

Cite This Study

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