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April 27, 2026Acta Neurologica TaiwanicaOpen Access

Cold Climate and Alzheimer’s Disease: A Narrative Review of Biomedical and Environmental Mechanisms

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Authors

KAKhaled A. Abdel-Sater

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Overview

Narrative review reveals cold exposure affects Alzheimer’s disease risk in aging populations, suggesting intervention strategies.

Key Points

  • This review investigates how cold environments may affect the development of Alzheimer’s disease through various physiological mechanisms.
  • Conducted a structured literature search in PubMed and Scopus databases up to July 2025.
  • Used Boolean operators for search: ('cold exposure' OR 'cold climate') AND ('Alzheimer's disease' OR 'neurodegeneration').
  • Presented a PRISMA-style flowchart for transparency in literature screening.
  • Cold exposure is linked to increased neuroinflammation and oxidative stress contributing to Alzheimer's pathology.
  • Epidemiological evidence indicates higher dementia risk in colder climates, adjusted for confounders.
  • Individuals with APOE ε4 allele show greater vulnerability to cold-related stresses.

Cite This Study

Khaled A. Abdel-Sater (2026) studied this question.

synapsesocial.com/papers/69eefd82fede9185760d4405https://doi.org/10.4103/ant.ant-d-25-00060
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