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April 27, 2026American Journal of Hematology

Cladribine With Low‐Dose Cytarabine and Venetoclax Alternating With Azacitidine and Venetoclax for Newly Diagnosed Acute Myeloid Leukemia

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Authors

TKTapan M. KadiaABAlex BatallerABAlexandre BazinetThe University of Texas MD Anderson Cancer Center

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Implication

Phase II study evaluates cladribine and venetoclax regimen for improved outcomes in older AML patients, indicating promising efficacy.

Key Points

  • The study aims to evaluate the efficacy of a regimen combining cladribine, cytarabine, and venetoclax in older or unfit patients with newly diagnosed acute myeloid leukemia.
  • Phase II clinical trial involving 190 older patients with newly diagnosed AML
  • Patients received cladribine plus low-dose cytarabine and venetoclax alternating with azacitidine plus venetoclax
  • Trial registered under ClinicalTrials.gov identifier: NCT03586609.
  • Complete remission rates were 84% and 75% for CR/CRi and MRD negative CR/CRi overall.
  • Median overall survival was 52 months, with 2- and 5-year OS rates of 60% and 45% respectively.
  • Among responders, 44% proceeded to allogeneic hematopoietic stem cell transplantation.

Cite This Study

Kadia et al. (2026) studied this question.

synapsesocial.com/papers/69eefd9bfede9185760d449bhttps://doi.org/10.1002/ajh.70328
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Genetic Risk Stratification and Outcomes Among Treatment-Naive Patients With AML Treated With Venetoclax and Azacitidine2024 · 149 citations
  2. 2Lower intensity therapy with cladribine/low dose cytarabine/venetoclax in older patients with acute myeloid leukemia compares favorably with intensive chemotherapy among patients undergoing allogeneic stem cell transplantation2024 · 17 citations
  3. 3Cladribine Combined with Low-Dose Cytarabine as Frontline Treatment for Unfit Elderly Acute Myeloid Leukemia Patients: Results from a Prospective Multicenter Study of Polish Adult Leukemia Group (PALG)2021 · 11 citations
  4. 4Patients With Acute Myeloid Leukemia and <i>RAS</i> Mutations Benefit Most From Postremission High-Dose Cytarabine: A Cancer and Leukemia Group B Study2008 · 155 citations