Ultrasonographic evaluation of familial Mediterranean fever patients with exertional leg pain: an overlooked component of the disease

April 22, 2026Lara D. VeekenOpen Access

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Key Points

This research aims to assess achilles tendon thickness and knee effusions in FMF patients experiencing exertional leg pain.
Evaluated pediatric patients with familial Mediterranean fever (FMF) who reported exertional leg pain (ELP).
Measured achilles tendon thickness and knee effusions via ultrasonography.
Proposed that findings reflect underlying subclinical inflammation associated with ELP.
Patients with ELP showed increased achilles tendon thickness compared to those without ELP.
Inter-attack knee effusions were identified as potential markers for subclinical inflammation in FMF patients.
Further research with larger cohorts is needed to clarify the clinical significance of observed changes.

Evaluates achilles tendon thickening in pediatric FMF patients with exertional leg pain, indicating potential structural changes.

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Küçükali et al. (2026) studied this question.

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