Beyond a BMI threshold of 38.2 kg/m², increasing BMI led to a significant decline in ventilatory capacity and an increased risk of pulmonary function impairment (OR 1.008; 95% CI 1.002-1.014).
Cross-Sectional (n=1,834)
Does BMI impact pulmonary function parameters in individuals with severe obesity?
In bariatric surgery candidates, BMI exhibits a non-linear relationship with pulmonary function, with a significant decline in ventilatory capacity and increased risk of impairment beyond a threshold of 38.2 kg/m².
Effect estimate: OR 1.008 (95% CI 1.002 to 1.014)
Introduction: The conflicting impact of obesity on pulmonary function has been observed. Our study aimed at exploring the relationship between BMI and pulmonary function parameters in individuals with obesity. Methods: This cross-sectional study included a consecutive cohort of bariatric surgery candidates with pulmonary function tests. BMI, analysed as both quartile-stratified groups and a continuous variable, was evaluated for associations with pulmonary function parameters and the risk of pulmonary impairment. Results: A total of 1834 patients with obesity (BMI range: 27.5–76.4 kg/m²) were included in our study. BMI exhibited a significantly positive correlation with FVC, FEV1, TLC, and FRC (P<0.001) and a negative correlation with FVC%pred, FEV1%pred, FEV1/FVC%, and RV/TLC (P<0.05). Non-linear relationships were found between BMI and both FVC%pred and FEV1%pred (P for non-linearity<0.01) after adjusting for covariables. Beyond the threshold BMI of 38.2 kg/m², FVC%pred and FEV1%pred declined significantly (FVC%pred: β=-0.522, 95% CI: -0.756 to -0.289; FEV1%pred: β=-0.435, 95% CI: -0.869 to -0.199), and the risk of pulmonary function impairment increased (OR=1.008, 95% CI:1.002 to 1.014). Conclusion: BMI exhibited a non-linear relationship with pulmonary function parameters. Beyond the critical threshold of 38.2 kg/m2, increasing BMI led to a significant decline in ventilatory capacity, concomitant with an amplified risk of pulmonary function impairment.
Nie et al. (Sat,) conducted a cross-sectional in Obesity (n=1,834). Body Mass Index was evaluated on Risk of pulmonary function impairment beyond BMI 38.2 kg/m² (OR 1.008, 95% CI 1.002 to 1.014). Beyond a BMI threshold of 38.2 kg/m², increasing BMI led to a significant decline in ventilatory capacity and an increased risk of pulmonary function impairment (OR 1.008; 95% CI 1.002-1.014).