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April 27, 2026Open Access

Engineered and Targeted Exosomes for Cancer Therapy: Recent Preclinical Advances

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Authors

NMNadiar M. MussinWest Kazakhstan Marat Ospanov State Medical UniversityKZKulyash R. ZhilisbayevaWest Kazakhstan Marat Ospanov State Medical UniversityABAkmaral Baspakova

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Implication

Mini-review summarizes preclinical advancements in engineered exosome cancer therapies, indicating promising results for treatment efficacy.

Key Points

  • The study aims to highlight recent advancements in engineered and targeted exosomes for cancer therapy.
  • Summarizes key preclinical advances in exosome engineering over the past 5 years.
  • Focuses on cargo-loading technologies and targeting strategies.
  • Discusses biodistribution control and therapeutic outcomes across major cancer models.
  • Engineered exosomes demonstrate enhanced tumor targeting and cellular uptake.
  • Specific modifications improve in vivo stability and therapeutic efficacy in cancer models.
  • Future challenges and perspectives for clinical application of exosome therapies are outlined.

Cite This Study

Mussin et al. (2025) studied this question.

synapsesocial.com/papers/69eefde9fede9185760d4b31https://doi.org/10.4103/wkrj.wkrj_6_26
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The biology , function , and biomedical applications of exosomes2020 · 11,021 citations
  2. 2Mesenchymal stem cell-derived exosomes as a new therapeutic strategy for liver diseases2017 · 645 citations
  3. 3Engineered exosomes for targeted co-delivery of miR-21 inhibitor and chemotherapeutics to reverse drug resistance in colon cancer2020 · 704 citations