What question did this study set out to answer?

To evaluate the relationship between inflammatory mediators (sICAM-1, IL-6) and brain damage markers (S-100β, NSE), and assess their correlation with injury severity and neurological outcome in severe traumatic brain injury.

May 1, 2001Journal of Neurotrauma

S-100 β Reflects the Extent of Injury and Outcome, Whereas Neuronal Specific Enolase Is a Better Indicator of Neuroinflammation in Patients With Severe Traumatic Brain Injury

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Authors

UPUlrike E. PleinesUniversity Hospital of Zurich MMMaria Cristina Morganti-KossmannBarrow Neurological Institute MRMario RancanTriemli Hospital

Discussion

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Implication

Prospective cohort study demonstrates distinct roles for S-100β in predicting neurological outcome and NSE in tracking neuroinflammation in severe traumatic brain injury, suggesting biomarker utility.

Key Points

To evaluate the relationship between inflammatory mediators (sICAM-1, IL-6) and brain damage markers (S-100β, NSE), and assess their correlation with injury severity and neurological outcome in severe traumatic brain injury.
Measured cerebrospinal fluid (CSF) and serum levels of S-100β, NSE, sICAM-1, and IL-6 over 2 weeks in 13 patients with severe traumatic brain injury.
Correlated biomarker concentrations with contusion sizes determined via CT scans and neurological recovery measured by the Glasgow Outcome Scale (GOS).
S-100β (CSF mean range: 2.7–81.4 ng/mL) and NSE (CSF mean range: 2.0–81.3 ng/mL) peaked during the first 3 posttraumatic days alongside increased sICAM-1 and IL-6.
CSF levels of S-100β (r = 0.63, p < 0.05) and NSE (r = 0.71, p < 0.05) significantly correlated with CT contusion sizes, while NSE correlated with IL-6 in both CSF (r = 0.64, p < 0.05) and serum (r = 0.56, p < 0.05).
Mean S-100β levels in both CSF (r = 0.78, p = 0.002) and serum (r = 0.82, p < 0.001) strongly correlated with Glasgow Outcome Scale scores, whereas NSE did not correlate with clinical outcome.

Cite This Study

Pleines et al. (2001) studied this question.

synapsesocial.com/papers/69ef23af585fcf98f748bd66 https://doi.org/10.1089/089771501300227297

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May 1, 2001Journal of Neurotrauma

S-100 β Reflects the Extent of Injury and Outcome, Whereas Neuronal Specific Enolase Is a Better Indicator of Neuroinflammation in Patients With Severe Traumatic Brain Injury

View Full Paper

Ask AI

Bookmark

Authors

UPUlrike E. PleinesUniversity Hospital of Zurich MMMaria Cristina Morganti-KossmannBarrow Neurological Institute MRMario RancanTriemli Hospital

Discussion

Member takes

Implication

Key Points

To evaluate the relationship between inflammatory mediators (sICAM-1, IL-6) and brain damage markers (S-100β, NSE), and assess their correlation with injury severity and neurological outcome in severe traumatic brain injury.
Measured cerebrospinal fluid (CSF) and serum levels of S-100β, NSE, sICAM-1, and IL-6 over 2 weeks in 13 patients with severe traumatic brain injury.
Correlated biomarker concentrations with contusion sizes determined via CT scans and neurological recovery measured by the Glasgow Outcome Scale (GOS).
S-100β (CSF mean range: 2.7–81.4 ng/mL) and NSE (CSF mean range: 2.0–81.3 ng/mL) peaked during the first 3 posttraumatic days alongside increased sICAM-1 and IL-6.
CSF levels of S-100β (r = 0.63, p < 0.05) and NSE (r = 0.71, p < 0.05) significantly correlated with CT contusion sizes, while NSE correlated with IL-6 in both CSF (r = 0.64, p < 0.05) and serum (r = 0.56, p < 0.05).
Mean S-100β levels in both CSF (r = 0.78, p = 0.002) and serum (r = 0.82, p < 0.001) strongly correlated with Glasgow Outcome Scale scores, whereas NSE did not correlate with clinical outcome.

Cite This Study

Pleines et al. (2001) studied this question.

synapsesocial.com/papers/69ef23af585fcf98f748bd66 https://doi.org/10.1089/089771501300227297

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