Why the study?
Does Egr-1 mediate the up-regulated expression of PDGF-B and other genes in mechanically injured arterial endothelial cells?
Population
Rat aorta and arterial endothelial cells
Comparison
Acute mechanical injury vs Unstimulated cells
Design
Preclinical
Authors
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Animal data implicate Egr-1 in post-injury PDGF-B upregulation; leaves open translation to clinical vascular interventions.
Does Egr-1 mediate the up-regulated expression of PDGF-B and other genes in mechanically injured arterial endothelial cells?
Egr-1 plays a crucial mechanistic role in up-regulating PDGF-B and other mediators following acute mechanical vascular injury.
Khachigian et al. (1996) studied this question.
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