The Macrophage in Cardiac Homeostasis and Disease
Key result
Cardiac macrophages emerge as a therapeutic target to minimize cardiomyocyte death and treat HF.
Why the study?
Recent molecular studies have revealed significant complexity within cardiac macrophage populations, prompting a review of their origins, dynamics, cell surface markers, and functions in cardiac homeostasis and disease.
Design
Review
Authors
Discussion
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Member takes
Implication
Should not yet change HF practice; leaves open which macrophage functions to target therapeutically in trials.
PICO
P
Population
Cardiovascular disease, myocarditis, and myocardial infarction
Cite This Study
Lavine et al. (2018) conducted a review in Cardiovascular disease, myocarditis, and myocardial infarction. Cardiac macrophages have diverse and dichotomous functions, making them an emerging focus for therapeutic strategies aimed at minimizing cardiomyocyte death and treating heart failure.