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Propofol clearance increases throughout infancy to reach 92% that reported in adults (1.93 L.min.70 kg⁻¹ ) by 6 months postnatal age and infusion regimens should reflect clearance maturation and be cognizant of adverse effects from concentrations greater than the target plasma concentration. Predicted concentrations using a published general purpose pharmacokinetic propofol model were similar to those determined using a new parameter set using richer neonatal and infant data.
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Morse et al. (2019) studied this question.
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