Why the study?
Does glucose-induced impairment of DDAH contribute to endothelial vasodilator dysfunction in diabetes mellitus?
Population
Diabetes Mellitus (DM)
Design
Preclinical
Authors
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Hypothesis-generating for DDAH-ADMA pathway in diabetic endothelial dysfunction; human studies required before clinical relevance.
Does glucose-induced impairment of DDAH contribute to endothelial vasodilator dysfunction in diabetes mellitus?
Glucose-induced DDAH impairment leads to ADMA accumulation, providing a mechanistic link to endothelial dysfunction in diabetes.
Lin et al. (2002) studied this question.
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