August 29, 2000Circulation
Impact of Diabetes on Long-Term Prognosis in Patients With Unstable Angina and Non–Q-Wave Myocardial Infarction
Key result
Diabetes confers equivalent long-term morbidity and mortality to established cardiovascular disease after unstable angina.
Why the study?
Hospitalization for unstable angina or non-Q-wave myocardial infarction predicts high 2-year morbidity and mortality, especially in patients with diabetes.
Does diabetes worsen long-term morbidity and mortality in patients hospitalized for unstable angina or non-Q-wave myocardial infarction?
Population
Patients hospitalized for unstable angina or non-Q-wave myocardial infarction
Comparison
Diabetic patients vs nondiabetic patients
Design
Observational cohort study
Follow-up
2 years
Authors
Discussion
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Member takes
Implication
Supports diabetes as CAD risk equivalent in unstable disease; observational data leaves open need for prospective confirmation.
Key Points
- Evaluate the long-term impact of diabetes mellitus on morbidity and mortality in patients hospitalized for unstable angina or non-Q-wave myocardial infarction.
- Tracked two-year clinical outcomes following hospitalization for unstable coronary artery disease.
- Stratified patients by diabetes status and presence of prior cardiovascular disease to assess comparative prognostic risks.
- Hospitalization for unstable angina or non-Q-wave myocardial infarction associates with substantial two-year morbidity and mortality, with significantly worse outcomes in diabetic individuals.
- Diabetic patients without prior cardiovascular disease experience long-term morbidity and mortality rates comparable to nondiabetic patients with established cardiovascular disease.
Study Design
Type
Observational
Structured PICO
Does diabetes worsen long-term morbidity and mortality in patients hospitalized for unstable angina or non-Q-wave myocardial infarction?
P
Population
Patients hospitalized for unstable angina or non-Q-wave myocardial infarction, evaluated for the prognostic impact of diabetes on long-term morbidity and mortality.
E
Exposure
Diabetes (as a risk factor/exposure)
C
Comparator
No diabetes
O
Outcome
2-year morbidity and mortalityhard clinical
Diabetes is a major risk factor for long-term morbidity and mortality in patients with unstable angina or non-Q-wave MI, conferring a risk equivalent to having established cardiovascular disease.
Cite This Study
Malmberg et al. (2000) conducted an observational in Unstable angina and non-Q-wave myocardial infarction. Diabetes vs. No diabetes was evaluated on Long-term morbidity and mortality. Diabetic patients without prior cardiovascular disease have the same long-term morbidity and mortality as nondiabetic patients with established cardiovascular disease after unstable angina or NQMI.