Why the study?
Does chronic beta-blocker treatment with bucindolol improve left ventricular function in patients with heart failure from systolic dysfunction?
Does chronic beta-blocker treatment with bucindolol improve left ventricular function in patients with heart failure from systolic dysfunction?
Bucindolol provides a dose-dependent improvement in left ventricular function in patients with heart failure due to systolic dysfunction.
Supports bucindolol titration in HFrEF; confirms beta-blockade benefits on LV function.
In heart failure from systolic dysfunction, beta-blockade with bucindolol produces a dose-related improvement in and prevents deterioration of left ventricular function.
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Bristow et al. (1994) studied this question.
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