Autonomic mechanisms in ventricular fibrillation induced by myocardial ischemia during exercise in dogs with healed myocardial infarction. An experimental preparation for sudden cardiac death.
Why the study?
Does left stellectomy prevent ventricular fibrillation induced by myocardial ischemia during exercise in dogs with healed myocardial infarction?
Population
57 chronically instrumented dogs
Comparison
Left circumflex coronary artery occlusion for 2… vs Normal dogs vs dogs with infarction; dogs with…
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Animal data suggest sympathetic denervation may prevent ischemic VF; leaves open translation to human post-MI care.
Structured PICO
Does left stellectomy prevent ventricular fibrillation induced by myocardial ischemia during exercise in dogs with healed myocardial infarction?
P
Population
57 chronically instrumented dogs (n=15 normal controls, n=42 evaluated 1 month after production of an anterior myocardial infarction)
I
Intervention
Left circumflex coronary artery occlusion for 2 min during the last minute of an exercise stress test and extending through the first minute after cessation. In a subset of 14 dogs with infarction, left stellectomy was performed.
C
Comparator
Normal dogs vs dogs with infarction; dogs with infarction with vs without left stellectomy
O
Outcome
Incidence of ventricular fibrillationhard clinical
In a canine model of healed myocardial infarction, left stellectomy completely prevented ventricular fibrillation induced by acute ischemia during exercise, highlighting the role of autonomic reflexes in malignant arrhythmias.
Cite This Study
Schwartz et al. (1984) studied this question.