Comparison of warfarin versus antiplatelet therapy after surgical bioprosthetic aortic valve replacement

Figure 1. Incidence of outcome events by different antithrombotic exposures Kaplan-Meier estimates for (A) all-cause mortality, (B) ischaemic stroke and (C) haemorrhagic stroke during follow-up. The lines represent different antithrombotic exposures: single antiplatelet treatment (SAPT), warfarin, W+SAPT, dual antiplatelet treatment (DAPT) and no oral antithrombotic treatment.

Figure 2. The relative risk of outcome events by different antithrombotic exposures relative to SAPT forest plots describing the relative risk of (A) all-cause mortality, (B) ischaemic stroke and (C) haemorrhagic stroke by warfarin, warfarin+single antiplatelet treatment (SAPT), dual antiplatelet treatment (DAPT) and no antithrombotic treatment relative to SAPT in a crude model. The adjusted model included adjustment for age, sex, left ventricular ejection fraction (<0.30, 0.30–0.50, >0.50), diabetes, hypertension, heart failure and the continuously updated comorbidities; prior atrial fibrillation, prior thromboembolism (ie, ischaemic stroke, systemic embolism, pulmonary embolism and venous thromboembolism), prior major bleeding (ie, haemorrhagic stroke and hospitalisation for other bleeding), prior myocardial infarction, prior coronary intervention and coronary intervention at index valve replacement. The number of haemorrhagic strokes were low during exposure to DAPT (n=1) and no relative risk analysis was performed (C).