Why the study?
Is mitral valve prolapse associated with diffuse LV myocardial fibrosis and ventricular arrhythmias?
Is mitral valve prolapse associated with diffuse LV myocardial fibrosis and ventricular arrhythmias?
Diffuse myocardial fibrosis, indicated by reduced postcontrast T1 times, may contribute to ventricular arrhythmias and subclinical systolic dysfunction in patients with mitral valve prolapse.
May link diffuse fibrosis to ComVA risk in MVP; observational data leaves open causality and prospective validation.
MVP may be associated with diffuse LV myocardial fibrosis as suggested by reduced postcontrast T₁ times. Diffuse interstitial derangement is linked to subclinical systolic dysfunction, and may contribute to ComVA in MVP-related mitral regurgitation, even in the absence of focal fibrosis.
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Bui et al. (2016) studied this question.
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