November 21, 1985New England Journal of Medicine
Echocardiographically Documented Mitral-Valve Prolapse
Why the study?
What is the long-term prognosis of patients with echocardiographically documented mitral-valve prolapse, and can echocardiographic features predict complications?
Population
237 minimally symptomatic or asymptomatic patients with mitral-valve prolapse documented by echocardiography
Design
Cohort
Follow-up
mean 6.2 years (range, 1 to 10.4)
Authors
Discussion
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Member takes
Implication
Supports risk stratification by leaflet morphology in mitral-valve prolapse; hypothesis-generating pending prospective validation.
Structured PICO
What is the long-term prognosis of patients with echocardiographically documented mitral-valve prolapse, and can echocardiographic features predict complications?
P
Population
237 minimally symptomatic or asymptomatic patients with mitral-valve prolapse documented by echocardiography
C
Comparator
Matched control population (for survival analysis); patients with nonredundant valves (for complication analysis)
O
Outcome
Actuarial eight-year probability of survivalhard clinical
While most patients with mitral-valve prolapse have a benign course, echocardiography can identify high-risk subsets (e.g., redundant leaflets, LV diastolic dimension >60 mm) prone to severe complications.
Cite This Study
Nishimura et al. (1985) studied this question.