Population
23- to 33-wk-old male and female mice with cardiac-specific knockout of the EP4 receptor gene and littermate…
Comparison
Cardiac-specific knockout of the EP4 receptor gene vs Littermate controls (WT)
Design
Preclinical
Authors
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Suggests EP4 protects against age-related cardiomyopathy in males; hypothesis-generating for human therapies with noted sexual dimorphism.
Cardiac-specific EP4 knockdown in aged male mice leads to dilated cardiomyopathy, increased fibrosis, and reduced ejection fraction, highlighting a potential protective role of EP4 with notable sexual dimorphism.
Harding et al. (2009) studied this question.
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