Why the study?
Does prior beta-blocker therapy alter the circadian pattern of acute myocardial infarction incidence?
Population
1,741 patients with acute myocardial infarction from the ISAM Study
Comparison
Prior beta-adrenergic blocking therapy vs No prior beta-adrenergic blocking therapy
Design
Cohort
Authors
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Beta-blocker use was associated with loss of morning MI peak; hypothesis-generating for mechanism, needs prospective confirmation.
Does prior beta-blocker therapy alter the circadian pattern of acute myocardial infarction incidence?
Prior beta-blocker therapy abolishes the morning peak incidence of acute myocardial infarction, suggesting a mechanism for their cardioprotective effect.
Willich et al. (1989) studied this question.
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