Why the study?
Does bilateral radiofrequency ablation of the proximal renal arteries reduce sympathetic activity and blood pressure in spontaneously hypertensive rats?
Does bilateral radiofrequency ablation of the proximal renal arteries reduce sympathetic activity and blood pressure in spontaneously hypertensive rats?
Radiofrequency renal denervation effectively lowers blood pressure and sympathetic activity in a rat model of established hypertension without altering sodium/water excretion or the renin-angiotensin system.
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Animal data support sympatholytic BP reduction by proximal renal denervation in SHR without RAS or natriuresis changes; leaves open human translation.
In hypertensive SHR, bilateral RF-ABL of the proximal renal arteries produced a sustained decease in sympathetic activity and BP without changes in sodium/water excretion or activity of the systemic/renal renin-angiotensin system.
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Gao et al. (2016) studied this question.
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