Why the study?
Does carvedilol improve left ventricular function, exercise performance, and symptoms in patients with stable heart failure of ischemic etiology?
Population
415 patients with stable heart failure of ischemic etiology (ejection fraction <45%)
Comparison
Carvedilol after a 2- to 3-week run-in phase on… vs Matching placebo
Design
RCT, Randomized to continued treatment with carvedilol or to matching placebo…
Follow-up
6 months
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Supports carvedilol to raise LVEF in ischemic HF; confirms beta-blocker effects on ventricular function.
Does carvedilol improve left ventricular function, exercise performance, and symptoms in patients with stable heart failure of ischemic etiology?
In patients with ischemic heart failure, 6 months of carvedilol therapy significantly improved left ventricular ejection fraction and dimensions, though it slightly worsened functional class symptoms.
A 1995 study studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: