September 27, 1984New England Journal of Medicine
Plasma Norepinephrine as a Guide to Prognosis in Patients with Chronic Congestive Heart Failure
Why the study?
Does resting plasma norepinephrine concentration predict mortality better than other cardiac performance indexes in patients with moderate to severe congestive heart failure?
Population
106 patients with moderate to severe congestive heart failure, mean age 54.8 years.
Comparison
Measurement of resting plasma norepinephrine… vs Other commonly measured indexes of cardiac…
Design
Cohort
Follow-up
1 to 62 months
Authors
Discussion
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Implication
Plasma norepinephrine independently predicts mortality in moderate-severe CHF; leaves open whether measurement should guide management or supplant other indexes.
Structured PICO
Does resting plasma norepinephrine concentration predict mortality better than other cardiac performance indexes in patients with moderate to severe congestive heart failure?
P
Population
106 patients (83 men and 23 women) with moderate to severe congestive heart failure (60 with coronary disease, 46 with cardiomyopathy), mean age 54.8 years.
I
Intervention
Measurement of resting plasma norepinephrine concentration
C
Comparator
Other commonly measured indexes of cardiac performance (hemodynamics, plasma renin activity, serum sodium, heart rate, stroke-work index)
O
Outcome
Mortality (subsequent risk of mortality)hard clinical
A single resting plasma norepinephrine measurement is an independent predictor of mortality in patients with moderate to severe chronic congestive heart failure, outperforming standard hemodynamic indices.
Cite This Study
Cohn et al. (1984) studied this question.