Why the study?
Is acute phase aldosterone concentration associated with mid- and long-term left ventricular remodelling after acute myocardial infarction?
Is acute phase aldosterone concentration associated with mid- and long-term left ventricular remodelling after acute myocardial infarction?
Elevated acute phase aldosterone is a biomarker for medium-term adverse LV remodeling post-MI, highlighting the potential early role of the mineralocorticoid system even in patients with LVEF >40%.
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Acute aldosterone may flag medium-term remodeling risk post-MI even with LVEF >40%; hypothesis-generating for early mineralocorticoid-targeted trials.
Aldosterone concentration in the acute phase was associated with adverse LV remodelling in the medium term, even in the subgroup of patients with LVEF >40%, suggesting a potential role of the mineralocorticoid system in post-MI adverse remodelling. Plasma aldosterone was no longer associated with LV remodelling in the long term (NCT01109225).
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Monzo et al. (2023) studied this question.
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