Why the study?
Chest pain is common and associated with increased cardiovascular risk in systemic lupus erythematosus, but emerging evidence suggests ischemia with no obstructive coronary arteries and coronary microvascular dysfunction are prevalent yet under-recognized causes.
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This review highlights the high prevalence of coronary microvascular dysfunction in SLE patients with chest pain and outlines diagnostic approaches for INOCA in this population.
Chest pain is a common symptom in patients with systemic lupus erythematosus, an autoimmune disease that is associated with increased cardiovascular morbidity and mortality. While chest pain mechanisms can be multifactorial and often attributed to non-coronary or non-cardiac cardiac etiologies, emerging evidence suggests that ischemia with no obstructive coronary arteries (INOCA) is a prevalent condition in patients with chest pain and no obstructive coronary artery disease. Coronary microvascular dysfunction is reported in approximately half of SLE patients with suspected INOCA. In this mini review, we highlight the cardiovascular risk assessment, mechanisms of INOCA, and diagnostic approach for patients with SLE and suspected CMD.
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Manchanda et al. (2022) studied this question.
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