May 27, 2020Cardiovascular ResearchOpen Access

Improving translational research in sex-specific effects of comorbidities and risk factors in ischaemic heart disease and cardioprotection: position paper and recommendations of the ESC Working Group on Cellular Biology of the Heart

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Biological sex modifies ischaemic heart disease presentation and cellular signalling, yet clinical comorbidities remain critically unaddressed in standard female and male cohorts.
Position paper synthesises mechanistic pathways and translational pitfalls in preclinical models, evaluating how risk factors modify ischaemia reperfusion injury across both sexes.
Highlights the urgent need to integrate comorbidities and biological sex into experimental designs, aiming to improve translational cardioprotection and female cardiovascular outcomes.

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Implication

Position paper reveals sex-specific comorbidity impacts in ischaemic heart disease preclinical models, highlighting recommendations to advance cardioprotective translational research.

Cite This Study

Perrino et al. (2020) studied this question.

synapsesocial.com/papers/69effa02bce9831ba4f73943 https://doi.org/10.1093/cvr/cvaa155

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Implication

Position paper reveals sex-specific comorbidity impacts in ischaemic heart disease preclinical models, highlighting recommendations to advance cardioprotective translational research.

Improving translational research in sex-specific effects of comorbidities and risk factors in ischaemic heart disease and cardioprotection: position paper and recommendations of the ESC Working Group on Cellular Biology of the Heart

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Implication

Cite This Study

Improving translational research in sex-specific effects of comorbidities and risk factors in ischaemic heart disease and cardioprotection: position paper and recommendations of the ESC Working Group on Cellular Biology of the Heart

Key Points

Discussion

Implication

Cite This Study

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