July 7, 2016Biology of Sex DifferencesOpen Access

Male and female hypertrophic rat cardiac myocyte functional responses to ischemic stress and β-adrenergic challenge are different

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Why the study?

Does pre-existing cardiac hypertrophy differentially modulate the responses of male and female cardiomyocytes to ischemic and adrenergic stress?

Structured PICO

Does pre-existing cardiac hypertrophy differentially modulate the responses of male and female cardiomyocytes to ischemic and adrenergic stress?

Population

n=55 rats (15 male NHR, 13 female NHR, 14 male HHR, 13 female HHR). Novel normotensive custom-derived hypertrophic heart rat (HHR) and control strain normal heart rat (NHR).

Intervention

In vitro simulated ischemia (20 min) and reperfusion (30 min) protocol, and beta-adrenergic challenge (10 nM isoproterenol for 5 min) on isolated ventricular cardiomyocytes.

Comparator

Normal heart rat (NHR) cardiomyocytes and baseline conditions.

Outcome

Cardiomyocyte morphologic and electromechanical functional responses (Ca2+ handling, twitch amplitude, shortening) to ischemic stress and beta-adrenergic challenge.surrogate

Cardiac hypertrophy produces dramatically different basal and stress-induced pathophenotypes in female- and male-origin cardiomyocytes, highlighting the need for sex-specific post-ischemic support strategies.

Discussion

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Implication

Sex-specific cardiomyocyte responses to ischemia in hypertrophy warrant caution in women; leaves open clinical translation and targeted trials.

Cite This Study

Bell et al. (2016) studied this question.

synapsesocial.com/papers/6a762918cd662f67b2fbde28 https://doi.org/10.1186/s13293-016-0084-8

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Implication

Sex-specific cardiomyocyte responses to ischemia in hypertrophy warrant caution in women; leaves open clinical translation and targeted trials.

Male and female hypertrophic rat cardiac myocyte functional responses to ischemic stress and β-adrenergic challenge are different

Structured PICO

Discussion

Implication

Cite This Study

Male and female hypertrophic rat cardiac myocyte functional responses to ischemic stress and β-adrenergic challenge are different

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider