Why the study?
Does coronary flow reserve predict adverse cardiovascular long-term outcomes in patients with angiographically normal or mildly diseased coronary arteries?
Does coronary flow reserve predict adverse cardiovascular long-term outcomes in patients with angiographically normal or mildly diseased coronary arteries?
Microvascular dysfunction, assessed by coronary flow reserve, independently predicts long-term adverse cardiovascular outcomes in patients with normal or mildly diseased coronary arteries.
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May refine long-term risk stratification by coronary flow reserve in nonobstructive disease; leaves open whether targeting microvascular dysfunction improves outcomes.
Coronary flow reserve in normal to mildly diseased arteries is an independent predictor of long-term prognosis of atherosclerosis within the next decade.
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Britten et al. (2004) studied this question.
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