Why the study?
Does nitroprusside have a different vasorelaxant effect compared to nitroglycerin in the human radial artery in vitro?
Does nitroprusside have a different vasorelaxant effect compared to nitroglycerin in the human radial artery in vitro?
In vitro testing suggests sodium nitroprusside may be preferable to nitroglycerin for postoperative radial artery vasodilation due to a lower risk of tolerance.
SNP may warrant consideration to limit tolerance in radial grafts; hypothesis-generating and requires clinical validation before practice change.
Both NTG and SNP are potent vasodilators in the RA. NTG may have more potent effects in certain situations (constriction related to thromboxane A2). However, tolerance to NTG may develop. A cross tolerance to SNP may exist but the effect is weak so that SNP may be preferable to NTG as a vasodilator in the RA postoperatively. Other vasodilators may be the drugs of choice under such circumstances.
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He et al. (1999) studied this question.
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