Key result
Prolonged vascular exposure to S-nitroso-N-acetylcysteine (SNAC) or nitric oxide induced a form of tolerance different from glyceryl trinitrate, with cross-tolerance to glyceryl trinitrate.
Population
U46619-contracted bovine isolated coronary artery rings
Comparison
Acute and prolonged exposure to S-nitrosothiol… vs Control rings or rings superfused with glyceryl…
Design
Preclinical
Authors
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May limit SNAC as sustained alternative to glyceryl trinitrate; leaves open clinical relevance from animal tolerance data.
While SNAC may acutely circumvent glyceryl trinitrate-induced tolerance, prolonged exposure to SNAC or NO induces a distinct form of tolerance with cross-tolerance to glyceryl trinitrate.
Henry et al. (1989) studied Isolated coronary artery preparation. S-nitrosothiols (SNAC, SNAP) and nitric oxide vs. Glyceryl trinitrate / control rings was evaluated on Relaxation responses and tolerance. Prolonged vascular exposure to S-nitroso-N-acetylcysteine (SNAC) or nitric oxide induced a form of tolerance different from glyceryl trinitrate, with cross-tolerance to glyceryl trinitrate.
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