Why the study?
Does N-acetylcysteine prevent or reverse tolerance to nitroglycerine in bovine coronary artery rings?
Population
Rings of bovine coronary artery
Comparison
N-acetylcysteine combined with nitroglycerine vs Nitroglycerine alone
Design
Preclinical
Authors
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NAC effects in bovine arteries do not support clinical use; leaves open whether sulfhydryl repletion mitigates NTG tolerance in patients.
Does N-acetylcysteine prevent or reverse tolerance to nitroglycerine in bovine coronary artery rings?
N-acetylcysteine potentiates the vasodilator response to nitroglycerine and prevents or reverses in vitro tolerance in bovine coronary arteries, suggesting a role for sulfhydryl depletion in NTG tolerance.
Torresi et al. (1985) studied this question.
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