Nitrate tolerance in epicardial arteries or in the venous system is not reversed by N-acetylcysteine in vivo, but tolerance-independent interactions exist.
Population
Dogs and in vitro purified guanylate cyclase.
Comparison
N-acetylcysteine (100 mg/kg i.v.) vs Nitroglycerin alone / baseline responsiveness
Design
Preclinical
Authors
Discussion
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Member takes
Implication
N-acetylcysteine does not reverse nitroglycerin tolerance in dogs; leaves open tolerance-independent augmentation for human investigation.
Structured PICO
P
Population
Dogs (n=29 total; 12 with nitroglycerin-specific tolerance induced by 5-6 days of 1.5 micrograms/kg/min i.v. nitroglycerin, and 17 nontolerant dogs) and in vitro purified guanylate cyclase.
I
Intervention
N-acetylcysteine (100 mg/kg i.v.)
C
Comparator
Nitroglycerin alone / baseline responsiveness
O
Outcome
Nitrate responsiveness of epicardial arteries and of the venous system (assessed as changes in effective vascular compliance)surrogate
N-acetylcysteine does not reverse in vivo nitrate tolerance in epicardial arteries or veins, though it can augment nitroglycerin-induced dilation in a tolerance-independent manner.
Cite This Study
Münzel et al. (1989) studied this question.