Why the study?
Does nitrate tolerance impair endogenous and exogenous NO-mediated vasodilation in vivo?
Population
Conscious chronically catheterized rats
Comparison
Nitrate tolerance induced by a 72-h intravenous… vs Nontolerant state and NTG-vehicle
Design
Preclinical
Follow-up
72 hours
Authors
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Suggests cross-tolerance to NO-mediated vasodilation in this model; leaves open clinical translation and NAC effects in humans.
Does nitrate tolerance impair endogenous and exogenous NO-mediated vasodilation in vivo?
Nitrate tolerance in vivo causes cross-tolerance to NO-mediated vasodilation from both exogenous and endogenous sources, which can be partially restored by N-acetylcysteine.
BECHLAURSEN et al. (1996) studied this question.
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