Do corticosteroids reduce mortality or improve cardiac function in people diagnosed with viral myocarditis and low LVEF?
Current evidence does not support the use of corticosteroids to reduce mortality in viral myocarditis with low LVEF, highlighting the need for high-quality, large-scale RCTs.
For people diagnosed with viral myocarditis and low LVEF, corticosteroids do not reduce mortality. They may improve cardiac function but the trials were of low quality and small size so this finding must be regarded as uncertain. High-quality, large-scale RCTs should be careful designed to determine the role of corticosteroid treatment for viral myocarditis. Adverse events should also be carefully evaluated.
Chen et al. (Fri,) studied this question.