Outcomes Following Radiofrequency Renal Denervation According to Antihypertensive Medications: Subgroup Analysis of the Global SYMPLICITY Registry DEFINE

Figures

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  Figure 1.. Bar graph showing systolic blood pressure (SBP) changes from baseline (BL) and comparisons between 0 to 3 and ≥4 medication classes. A, Office SBP changes from BL and blood pressure (BP) change comparison between 0 to 3 and ≥4 medication classes. B, Twenty-four–hour ambulatory SBP changes from BL and BP change comparison between 0 to 3 and ≥4 medication classes. Error bars represent standard error. All BP changes compared with BL in both groups had t test P value <0.0001. P values for between-group comparisons were adjusted for each BL SBP displayed on top of the bars, using ANCOVA test.

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  Figure 2.. Office systolic blood pressure (SBP) and medication changes at 36 months after radiofrequency renal denervation. A, Bar graphs with office SBP changes at 36 months from baseline in patients who decreased, had no change or increased medications. All blood pressure (BP) changes compared with baseline in these groups had t test P value <0.0001. B, Left-hand bar graph representing the overall population with changes in systolic BP from baseline at 36 months corresponding with increase, decrease, and no change in medication classes at 36 months. The right-hand bar graphs show a comparison in medication changes between 0 to 3 and ≥4 antihypertensive medication classes. Error bars represent SE.

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  Figure 3.. Different categories of baseline antihypertensive medication class combos and their office systolic blood pressure (SBP) change through 36 months. Category 1: 1 to 3 antihypertensive medication classes including ACE (angiotensin-converting enzyme) inhibitor or angiotensin receptor blocker (ARB), calcium channel blocker, diuretic, and β-blocker. Category 2: 4 to 6 classes of antihypertensive medications including ACE inhibitor or ARB, calcium channel blocker, diuretic, β-blocker, aldosterone antagonist, and α-adrenergic blocker. Category 3: 1 to 4 medications including any of the following reserve antihypertensive medication classes: centrally acting sympatholytics, direct-acting vasodilators, and direct renin inhibitors. Category 4: any class combination of ≥5 antihypertensive medications. Category 5: any class combination including ACE inhibitor and ARB. The bar graphs show office SBP change from baseline for each category of medication class combos. Error bars represent SE. RDN indicates renal denervation.

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  Figure 4.. Bar graph showing systolic blood pressure (SBP) changes from baseline (BL) in resistant hypertension patients on ≥3 antihypertensive medications with or without aldosterone antagonist (AA). A, Office SBP changes from BL. B, Twenty-four-hour ambulatory SBP changes from BL. All blood pressure (BP) changes compared with BL in these groups had t test P value <0.0001. P values were ANCOVA adjusted for each BL SBP as displayed below the bars.