Why the study?
Does the combination of Ea velocity and ejection fraction assessed by Doppler tissue imaging predict affected genotype in individuals with preclinical hypertrophic cardiomyopathy?
Does the combination of Ea velocity and ejection fraction assessed by Doppler tissue imaging predict affected genotype in individuals with preclinical hypertrophic cardiomyopathy?
The combination of Ea velocity and ejection fraction using Doppler tissue imaging can predict the presence of beta-MHC mutations in preclinical hypertrophic cardiomyopathy before the development of left ventricular hypertrophy.
May support noninvasive preclinical HCM genotype identification; hypothesis-generating and requires prospective validation before practice change.
Abnormalities of diastolic function assessed by Doppler tissue imaging precede the development of LVH in individuals with HCM caused by beta -MHC mutations. Although Ea velocity alone was not sufficiently sensitive as a sole diagnostic criterion, the combination of Ea velocity and EF was highly predictive of affected genotype in individuals without overt manifestations of HCM.
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Ho et al. (2002) studied this question.
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