March 26, 2013Hypertension

Intensive Blood Pressure Lowering Increases Cerebral Blood Flow in Older Subjects With Hypertension

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Why the study?

Does intensive blood pressure lowering improve cerebral blood flow in older subjects with hypertension?

Structured PICO

Does intensive blood pressure lowering improve cerebral blood flow in older subjects with hypertension?

Population

37 individuals aged >70 years with a history of systolic hypertension on 1 or no BP lowering drugs, recruited from primary care (mean age 75±4 years, systolic BP >150 mm Hg).

Intervention

Intensive blood pressure lowering (target BP <130/80 mm Hg) for 12 weeks.

Comparator

Usual blood pressure lowering (target BP <140/85 mm Hg) for 12 weeks.

Outcome

Change in gray matter cerebral blood flow (CBF) determined using 3T arterial spin labeling MRI after 12 weeks of treatment.surrogate

Intensive blood pressure lowering (<130/80 mm Hg) in older hypertensive patients increases cerebral blood flow compared to usual targets, alleviating concerns of treatment-induced cerebral hypoperfusion.

Discussion

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Implication

Supports intensive BP lowering in older hypertensives without hypoperfusion risk; extends RCT evidence to cerebral perfusion outcomes.

Cite This Study

Tryambake et al. (2013) studied this question.

synapsesocial.com/papers/69effabebce9831ba4f73c99 https://doi.org/10.1161/hypertensionaha.112.200972

Topics

Hypertension management

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Intensive Blood Pressure Lowering Increases Cerebral Blood Flow in Older Subjects With Hypertension

Structured PICO

Discussion

Implication

Cite This Study

Topics

Intensive Blood Pressure Lowering Increases Cerebral Blood Flow in Older Subjects With Hypertension

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider