In young people with sudden cardiac death due to coronary artery disease, extra-coronary plaque is present in fewer than 20%, suggesting limited utility of screening for carotid or aortic plaque to predict coronary atherosclerosis.
Fewer than one in five people aged 1-50 years experiencing SCD from a coronary cause exhibited extra-coronary plaque, suggesting that in young people, severe atherosclerosis is not necessarily a concurrent systemic disease. This may limit the utility of screening for carotid or aortic plaque to predict coronary atherosclerosis on an individual level. Individuals with extra-coronary plaque were older with more established coronary disease.
Paratz et al. (Thu,) studied this question.