Why the study?
Is there an independent association between plasma Lipoprotein(a) values and the severity of coronary artery disease in patients undergoing coronary angiography?
Is there an independent association between plasma Lipoprotein(a) values and the severity of coronary artery disease in patients undergoing coronary angiography?
The apparent association between Lp(a) levels and coronary stenosis severity is largely attenuated by confounding factors, suggesting other variables significantly influence this relationship.
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Confounders largely explain Lp(a)-stenosis link; leaves open independent association in angiography patients.
To determine possible associations between lipoprotein(a) [Lp(a)] and the severity of coronary artery lesions, we measured lipid, apolipoprotein, and Lp(a) in a large population of Belgian patients (n = 1054) undergoing coronary angiography. In both women and men, univariate analysis demonstrated significant differences in the Lp(a) concentrations according to the severity of the coronary stenosis. However, after adjustment for possible confounding factors, many of these differences were attenuated, indicating that other variables that differentiate patients from control subjects also influence Lp(a) distribution. Differences in lipid, apolipoprotein, and Lp(a) concentrations between male and female patients are discussed.
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Labeur et al. (1992) studied this question.
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