Why the study?
Does prophylactic antithrombotic therapy (aspirin or warfarin) reduce ischemic stroke and systemic embolism in patients with nonrheumatic atrial fibrillation?
Population
Patients with nonrheumatic atrial fibrillation
Comparison
Aspirin or warfarin vs Aspirin compared with warfarin
Design
RCT
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Supports antithrombotic prophylaxis with aspirin or warfarin in nonrheumatic AF; confirms efficacy while leaving relative benefit unresolved.
Does prophylactic antithrombotic therapy (aspirin or warfarin) reduce ischemic stroke and systemic embolism in patients with nonrheumatic atrial fibrillation?
Prophylactic antithrombotic therapy with either aspirin or warfarin is effective in reducing the risk of stroke in patients with nonrheumatic atrial fibrillation.
A 1991 study studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: