April 28, 2026Journal of the American College of Cardiology
Effect of sleep loss on C-Reactive protein, an inflammatory marker of cardiovascular risk
Why the study?
Does sleep deprivation increase high-sensitivity C-reactive protein levels in healthy adults?
Population
20 healthy adult subjects (10 in Experiment 1, 10 in Experiment 2)
Comparison
Acute total sleep deprivation or short-term… vs 8.2 hours of nighttime sleep for 10 consecutive…
Design
RCT, randomly assigned to either 8.2 h or 4.2 h of nighttime sleep
Follow-up
Up to 10 days
Authors
Discussion
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Implication
Both acute total and short-term partial sleep deprivation elevate high-sensitivity CRP, providing a potential inflammatory mechanism linking sleep loss to cardiovascular morbidity.
Structured PICO
Does sleep deprivation increase high-sensitivity C-reactive protein levels in healthy adults?
P
Population
20 healthy adult subjects (10 in Experiment 1, 10 in Experiment 2)
I
Intervention
Acute total sleep deprivation (88 continuous hours awake) or short-term partial sleep deprivation (4.2 hours of nighttime sleep for 10 consecutive days)
C
Comparator
8.2 hours of nighttime sleep for 10 consecutive days (control group in Experiment 2)
O
Outcome
High-sensitivity C-reactive protein (hs-CRP) concentrationssurrogate
Both acute total and short-term partial sleep deprivation elevate high-sensitivity CRP, providing a potential inflammatory mechanism linking sleep loss to cardiovascular morbidity.
Cite This Study
Meier-Ewert et al. (2004) studied this question.