“Panting sign” as a clinical clue to heat stress in hypohidrotic ectodermal dysplasia

A 1-year-old male child, born of a non-consanguineous marriage, presented with sparse scalp hair and the absence of dentition since birth.Clinical examination revealed anhidrosis, an underdeveloped mandible, and thick, everted lips Figure 1a.e nails were normal.e starchiodine test revealed a complete absence of sweating.ere was no family history of similar complaints in a three-generation pedigree chart.e parents also reported a recurrent pattern during heat exposure or physical exertion: e child would become uncomfortable, protrude his tongue, and develop rapid, non-laboured open mouth breathing (panting-like breathing) Figure 1b.Dermoscopic examination of the chest demonstrated marked reduction of pinpoint white dots (eccrine duct openings/"pores"), supporting a diagnosis of hypohidrotic ectodermal dysplasia (HED) Figure 2.Genetic testing was not performed due to the financial constraints of the parents.Dermoscopy thus served as a useful, non-invasive adjunct to substantiate hypohidrosis in the absence of molecular confirmation.Conventionally, panting is regarded as a thermolytic strategy in non-human mammals, allowing evaporative cooling from the upper respiratory tract in the absence of sweating.is behavior is www.jsstd.