Discovery of Small Molecule Inhibitors of PCSK9 Using Virtual Screening as Potential Therapeutics for Atherosclerosis

Key Points

• The aim is to identify small molecule inhibitors of PCSK9 for potential use in treating atherosclerosis.
• Utilized virtual screening to identify small molecule inhibitors of PCSK9.
• Evaluated the impact of identified inhibitors on LDL cholesterol levels.
• Analyzed the efficacy of these molecules in vitro and in vivo.
• Identified several small molecule inhibitors that significantly reduce PCSK9 activity.
• Found that these inhibitors lower LDL cholesterol levels effectively.
• Demonstrated potential for further development into therapeutics for atherosclerosis.