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April 28, 2026International Journal of Retina and VitreousOpen Access

Fluocinolone acetonide implant in diabetic macular edema: sustained benefits and effects of following prior therapy

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Authors

PNPhilipp NecpalKKKlemens P. KaiserRKRon C. Kroener

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Overview

Retrospective study evaluates long-term effects of fluocinolone acetonide in diabetic macular edema, suggesting earlier intervention is beneficial.

Key Points

  • This study aims to assess long-term effects of fluocinolone acetonide implants in diabetic macular edema and the impact of previous anti-VEGF treatment on outcomes.
  • Retrospective, single-center study including 74 eyes from 47 patients with diabetic macular edema.
  • Measured best-corrected visual acuity, central retinal thickness, and treatment history over a median follow-up of 40 months.
  • Statistical testing analyzed changes in clinical outcomes and correlations with prior anti-VEGF exposure.
  • Fluocinolone acetonide significantly reduced central retinal thickness by a median of 75.5 µm (p<0.001).
  • Greater reduction in CRT was noted in eyes with fewer than six prior anti-VEGF injections (−93 µm) compared to six or more (−65 µm; p=0.015).
  • Best-corrected visual acuity improved by +3.95 ETDRS letters overall, with a larger gain of +7.53 letters in less pretreated eyes.

Cite This Study

Necpal et al. (2026) studied this question.

synapsesocial.com/papers/69f04e9b727298f751e7278chttps://doi.org/10.1186/s40942-026-00861-y
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Real-life results after the administration of a single 0.19 mg fluocinolone acetonide (ILUVIEN®) implant in patients with refractory diabetic macular edema2024
  2. 2Intravitreal fluocinolone acetonide implant for diabetic macular edema – 2-year results from IDEAL, a prospective German observational study2026
  3. 3Improvement in visual outcomes in diabetic macular edema through the reduction of macular thickness fluctuations using the 0, 19 mg fluocinolone acetonide implant2026
  4. 4Efficacy of fluocinolone acetonide implant in diabetic macular edema patients previously treated with dexamethasone implant: A systematic review and meta-analysis2025
  5. 5Use of intravitreal fluocinolone acetonide implant in inflammatory macular oedema2026 · 1 citations