Key result
Exceptionally rare synchronous oral and oropharyngeal epithelioid angiosarcoma requires immunohistochemistry for accurate diagnosis.
Highlights the first reported case of synchronous primary epithelioid angiosarcoma in the oral cavity and oropharynx and the necessity of immunohistochemistry for diagnosis.
Prompts IHC for atypical oral cavity tumors to avoid misdiagnosis; leaves open pathogenesis and management of synchronous epithelioid angiosarcoma.
Oral epithelioid angiosarcoma arising in the oral cavity is exceptionally rare. This case reports the first instance of synchronous primary epithelioid angiosarcoma in the oral cavity and oropharynx. Accurate diagnosis requires an understanding of the importance of immunohistochemistry to differentiate this vascular tumour from similar pathologic entities.
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Maloney et al. (2026) studied this question. Synchronous primary epithelioid angiosarcoma of the oral cavity and oropharynx is an exceptionally rare presentation requiring immunohistochemistry for accurate diagnosis.
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