Key result
A 78-year-old woman with maxillary angiosarcoma underwent maxillectomy and adjuvant chemoradiotherapy but experienced tumor spread and died from the disease 10 months postoperatively.
Case Report (n=1)
No
Oral angiosarcoma is a rare, aggressive neoplasia that can mimic other lesions, requiring comprehensive evaluation for accurate diagnosis and early multidisciplinary management.
Portends poor survival in maxillary angiosarcoma despite multimodal therapy; leaves open optimal strategies for this rare malignancy.
Angiosarcoma is a rare and aggressive malignant mesenchymal neoplasia developing from endothelial cells, comprising only 2 % of soft tissues sarcomas. While primarily affecting soft tissues and skin, its occurrence in the oral cavity is exceptionally rare (1.6 %). We present the case of a 78-year-old woman with a nodular gingival lesion initially suspected as squamous cell carcinoma. Despite an uneventful postoperative course following maxillectomy, the histological examination revealed angiosarcoma. Discussion highlights the diagnostic challenges due to its varied clinical and histological presentation, often mimicking other lesions. Treatment involves complete surgical excision, followed by adjuvant chemotherapy and radiotherapy. However, the prognosis remains poor, with a high recurrence rate and metastatic potential. Our case underscores the importance of accurate diagnosis through comprehensive clinical, radiological, and histological evaluation, emphasizing the need for early detection and multidisciplinary management to improve outcomes in angiosarcoma patients. • Oral angiosarcoma is an aggressive neoplasia with a poor prognosis. • Oral angiosarcoma often mimic other lesions inducing a diagnostic delay, such as begnin tumor. • Early detection and multidisciplinary management improve outcomes in oral angiosarcoma.
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Kamdem et al. (2025) conducted a case report in Maxillary angiosarcoma (n=1). Maxillectomy, adjuvant chemotherapy, and radiotherapy was evaluated on Clinical outcome. A 78-year-old woman with maxillary angiosarcoma underwent maxillectomy and adjuvant chemoradiotherapy but experienced tumor spread and died from the disease 10 months postoperatively.
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